In 2015, an earthquake of 7.8 magnitude displaced over 6.6 million in Kathmandu, Nepal. Three years later, the country struggles to rebuild its capital. The aim of this study was to investigate a construction system, produced from locally sourced materials, that can aggregate and deploy as self-built, habitable infrastructure. The study focused on the relationships between material resonance, earthquake-resistant structures, and fabrication processes. An agent-based form-finding algorithm was developed using knowledge acquired through physical prototyping of mycelium-based composites to generate complex geometries that increase earthquake resistance, optimise material usage, and enhance spatial occupation. The results show compelling evidence for a construction methodology to design and construct a 3-4-storey building. The scope of work contributes to advancements in bioengineering, confirming easy-to-grow, light-weight mycelium composites as viable structural materials for construction.